TU Berlin

Environmental MicrobiologyGenetics

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Publications of the work group Genetics since 2000



Development and application of GFP-based monitoring tools to estimate conjugative plasmid transfer in multispecies biofilms (BMBF/ESA Plasmidtransfer/MISSEX) more to: Missex

FWF Project


Bacterial conjugation: studies on the conjugative plasmid transfer mechanisms in Gram-positive bacteria (simplified type IV secretion mechanism), (FWF, collaboration project with Prof. Dr. W. Keller, Universit├Ąt Graz) more to: FWF Project


Our aim is to elucidate the role of the protein components in the assembly of a conjugative T4S-like machinery in Gram-positive bacteria. We will verify our in vivo and in vitro protein-protein interaction studies and computer predictions by localization of the T4SLS proteins in Enterococcus faecalis cell compartments by cell fractionation followed by Western Blot, immunogold transmission electron microscopy and immunofluorescence microscopy. more to: DAAD PPP


Objectives and individual tasks of the joint project:Work carried out in India: Screening for both conjugative plasmids from gram positive bacteria and gram negative bacteria from highly contaminated soil by the triparental mating method. Isolation and incompatibility group/oriT-family-based characterization of conjugative plasmids from gram positive and gram negative bacteria from differently contaminated soils from various origins more to: DST-DAAD


Increasing resistance of bacteria to commonly used antibiotics has become a serious problem. Food bacteria could act as reservoirs for resistance genes. There are very few systematic studies on antibiotic resistant lactic acid bacteria (LAB) in traditional fermented dairy and meat products. The project focuses on monitoring of antibiotic resistance in LAB isolates from Turkish dairy and meat products, as well as on the characterisation of resistance and transfer (tra) genes carried by them. Main objectives are the identification of lactic acid bacteria to species level in fermented Turkish food products, determination of their inherent antibiotic resistance and their horizontal transmissibility. (Supported by the BMBF) more to: STC (BMBF)


The COMICS project (Concordia Microbial Dynamics) based on the MISSEX project focuses on analysis of the microbial diversity of the bacterial populations from the Antarctica Research Station CONCORDIA. Microbial diversity will be analysed on crew samples and on samples from the technical equipment of the research station. Emphasis is laid on Gram-positive (G+) nosocomial and pathogenic bacteria and their plasmids. Plasmids will be analysed with respect to size, conformation, DNA transfer and mobilization abilities. more to: COMICS

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